Abstract
A series of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo[5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Proliferation / drug effects
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Cells, Cultured
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Drug Design*
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Enzyme Activation / drug effects
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Humans
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Imidazoles / chemical synthesis
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Imidazoles / pharmacology
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Inhibitory Concentration 50
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Models, Molecular
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Molecular Structure
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Protein Kinase Inhibitors / chemical synthesis*
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Pyridines / chemical synthesis
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Pyridines / chemistry
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Pyridines / pharmacology
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacology*
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Structure-Activity Relationship
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Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors*
Substances
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Imidazoles
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Protein Kinase Inhibitors
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Pyridines
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Quinolones
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Vascular Endothelial Growth Factor Receptor-2